MoA
Exosomal miRNA
Mechanism of Action
The Exometa™ Regenerative Framework
Exometa™
Exometa™ leverages the mechanisms of action (MoA) of two variants of umbilical-cord-derived exosomes—Wharton's Jelly Mesenchymal Stem Cells (HWJ) and Umbilical-Cord Vein Endothelial Cells (HUV) —to orchestrate tissue regeneration in the Neurovascular Unit (NVU), Renal Parenchyma, and in many other tissue microenvironments.
The therapeutic effect is not driven by bulk growth factor protein transfer, but by a targeted miRNA silencing payload. Exometa™ overrides chronic injury signaling through a Double-Negative Logic: silencing endogenous genetic brakes to reactivate the body's intrinsic regeneration programs.
Exometa™ leverages the mechanisms of action (MoA) of two variants of umbilical-cord-derived exosomes—Wharton's Jelly Mesenchymal Stem Cells (HWJ) and Umbilical-Cord Vein Endothelial Cells (HUV) —to orchestrate tissue regeneration in the Neurovascular Unit (NVU), Renal Parenchyma, and in many other tissue microenvironments.
The therapeutic effect is not driven by bulk growth factor protein transfer, but by a targeted miRNA silencing payload. Exometa™ overrides chronic injury signaling through a Double-Negative Logic: silencing endogenous genetic brakes to reactivate the body's intrinsic regeneration programs.
Core Mechanism:
The "Double-Negative" Lever
The framework's efficacy is anchored in the precise suppression of two key inhibitory nodes:
The framework's efficacy is anchored in the precise suppression of two key inhibitory nodes:
PTEN Silencing (Survival & Proliferation)
PTEN Silencing (Survival & Proliferation)
Exosomal miR-302d-3p and miR-23a-3p, delivered by the Exometa-HWJ fraction, targeting the tumor suppressor PTEN. By removing this "brake", the PI3K-Akt pathway is unlocked, driving robust cell survival and metabolic restoration.
Exosomal miR-302d-3p and miR-23a-3p, delivered by the Exometa-HWJ fraction, targeting the tumor suppressor PTEN. By removing this "brake", the PI3K-Akt pathway is unlocked, driving robust cell survival and metabolic restoration.
SPRED1 Silencing (Angiogenesis & Remodeling)
SPRED1 Silencing (Angiogenesis & Remodeling)
Exosomal miR-126 and miR-199a-3p, delivered by the Exometa-HUV fraction, targeting SPRED1. This releases the MAPK/ERK pathway, promoting VEGF sensitivity and functional vascular sprouting without the leakiness associated with supraphysiological VEGF administration.
Exosomal miR-126 and miR-199a-3p, delivered by the Exometa-HUV fraction, targeting SPRED1. This releases the MAPK/ERK pathway, promoting VEGF sensitivity and functional vascular sprouting without the leakiness associated with supraphysiological VEGF administration.
Exometa™ Four-Stage Regenerative Cascade
Stage
Exosomes Source
Primary miRNA Payload
Target Genes* Pathway
Cellular Effect
Functional Outcome
RESCUE
EXOMETA-HWJ
miR-302d-3p
miR-23a-3p
PTEN*
PI3K-Akt Pathway
Decreased BAX expression; Stabilized mitochondrial membrane potential
Halting Apoptosis
Preservation of cell viability in the peri-injury zone
RESOLVE
EXOMETA-HWJ
miR-146a-5p
miR-1246
IRAK1*
TRAF6
NF-kB Axis
Suppression of pro-inflammatory cytokine release
M1 to M2 Macrophage Polarization
Extinguishing Inflammation
Debris clearance and establishment of a permissive repair environment
REBUILD
EXOMETA-HUV
miR-126
miR-199a-3p
SPRED1*
MAPK/ERK Pathway
Increased VEGF sensitivity
Endothelial sprouting and parenchymal proliferation
Physiologic Angiogenesis Restoration of vascular networks without pathological leakiness
REFINE
EXOMETA-HWJ
miR-1283
miR-146a
TGF-beta*
ALK5 Smad2/3 Signaling
Decreased alpha-SMA and Collagen deposition
Preservation of ALK1/Smad1/5 maturation signaling
Preventing Fibrosis Functional tissue architecture maintained; scar formation inhibited
Stage
Exosomes Source
Primary miRNA Payload
Target Genes* Pathway
Cellular Effect
Functional Outcome
RESCUE
EXOMETA-HWJ
miR-302d-3p
miR-23a-3p
PTEN*
PI3K-Akt Pathway
Decreased BAX expression; Stabilized mitochondrial membrane potential
Halting Apoptosis
Preservation of cell viability in the peri-injury zone
RESOLVE
EXOMETA-HWJ
miR-146a-5p
miR-1246
IRAK1*
TRAF6
NF-kB Axis
Suppression of pro-inflammatory cytokine release
M1 to M2 Macrophage Polarization
Extinguishing Inflammation
Debris clearance and establishment of a permissive repair environment
REBUILD
EXOMETA-HUV
miR-126
miR-199a-3p
SPRED1*
MAPK/ERK Pathway
Increased VEGF sensitivity
Endothelial sprouting and parenchymal proliferation
Physiologic Angiogenesis Restoration of vascular networks without pathological leakiness
REFINE
EXOMETA-HWJ
miR-1283
miR-146a
TGF-beta*
ALK5 Smad2/3 Signaling
Decreased alpha-SMA and Collagen deposition
Preservation of ALK1/Smad1/5 maturation signaling
Preventing Fibrosis Functional tissue architecture maintained; scar formation inhibited
Want to Book a Call?
Want to Pioneer Better Health Solutions? Get in Touch with Us
Want to Book a Call?